MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease

Sickle cell disease (SCD) is associated with hemolysis, vascular inflammation, and organ damage. Affected patients experience chronic painful vaso-occlusive events requiring hospitalization. Hypoxia-induced polymerization of sickle hemoglobin S (HbS) contributes to sickling of red blood cells (RBCs)...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Demers, Melanie, Sturtevant, Sarah, Guertin, Kevin R., Gupta, Dipti, Desai, Kunal, Vieira, Benjamin F., Li, Wenjing, Hicks, Alexandra, Ismail, Ayman, Gonçalves, Bronner P., Di Caprio, Giuseppe, Schonbrun, Ethan, Hansen, Scott, Musayev, Faik N., Safo, Martin K., Wood, David K., Higgins, John M., Light, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948285/
https://ncbi.nlm.nih.gov/pubmed/33661300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003670
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