Unfolded and intermediate states of PrP play a key role in the mechanism of action of an antiprion chaperone

Prion and prion-like diseases involve the propagation of misfolded protein conformers. Small-molecule pharmacological chaperones can inhibit propagated misfolding, but how they interact with disease-related proteins to prevent misfolding is often unclear. We investigated how pentosan polysulfate (PP...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Petrosyan, Rafayel, Patra, Shubhadeep, Rezajooei, Negar, Garen, Craig R., Woodside, Michael T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2021
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936342/
https://ncbi.nlm.nih.gov/pubmed/33619087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010213118
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