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A Survey of Antiprion Compounds Reveals the Prevalence of Non-PrP Molecular Targets
Prion diseases are fatal neurodegenerative diseases caused by the accumulation of the misfolded isoform (PrP(Sc)) of the prion protein (PrP(C)). Cell-based screens have identified several compounds that induce a reduction in PrP(Sc) levels in infected cultured cells. However, the molecular targets o...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149362/ https://ncbi.nlm.nih.gov/pubmed/21610081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234393 |
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