A Survey of Antiprion Compounds Reveals the Prevalence of Non-PrP Molecular Targets

Prion diseases are fatal neurodegenerative diseases caused by the accumulation of the misfolded isoform (PrP(Sc)) of the prion protein (PrP(C)). Cell-based screens have identified several compounds that induce a reduction in PrP(Sc) levels in infected cultured cells. However, the molecular targets o...

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書誌詳細
主要な著者: Poncet-Montange, Guillaume, St. Martin, Susan J., Bogatova, Olga V., Prusiner, Stanley B., Shoichet, Brian K., Ghaemmaghami, Sina
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
Neurobiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149362/
https://ncbi.nlm.nih.gov/pubmed/21610081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234393
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