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Biology and Genetics of PrP Prion Strains
Prion diseases are a group of fatal neurodegenerative disorders caused by the misfolding of the cellular prion protein (PrP(C)) into a pathogenic conformation (PrP(Sc)). PrP(Sc) is capable of folding into multiple self-replicating prion strains that produce phenotypically distinct neurological disor...
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| Pubblicato in: | Cold Spring Harb Perspect Med |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538409/ https://ncbi.nlm.nih.gov/pubmed/27920025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026922 |
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