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Structural Biology of PrP Prions

Prion diseases are characterized by the deposition of amyloids, misfolded conformers of the prion protein. The misfolded conformation is self-replicating, by a mechanism solely enciphered in the conformation of the protein. Because of low solubility and heterogeneous aggregate sizes, the detailed at...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Perspect Med
Main Authors: Stubbs, Gerald, Stöhr, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453385/
https://ncbi.nlm.nih.gov/pubmed/28003279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a024455
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