A Survey of Antiprion Compounds Reveals the Prevalence of Non-PrP Molecular Targets

Prion diseases are fatal neurodegenerative diseases caused by the accumulation of the misfolded isoform (PrP(Sc)) of the prion protein (PrP(C)). Cell-based screens have identified several compounds that induce a reduction in PrP(Sc) levels in infected cultured cells. However, the molecular targets o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Poncet-Montange, Guillaume, St. Martin, Susan J., Bogatova, Olga V., Prusiner, Stanley B., Shoichet, Brian K., Ghaemmaghami, Sina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Neurobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149362/
https://ncbi.nlm.nih.gov/pubmed/21610081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234393
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg