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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells

During prion diseases, a normally benign, host protein, denoted PrP(C), undergoes alternative folding into the aberrant isoform, PrP(Sc). We used ELISA assays to identify and confirm hits in order to develop leads that reduce PrP(Sc) in prion-infected dividing and stationary-phase mouse neuroblastom...

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Главные авторы:	Silber, B. Michael, Gever, Joel R., Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R., Widjaja, Kartika, Irwin, John J., Rao, Satish, Jacobson, Matthew P., Ghaemmaghami, Sina, Prusiner, Stanley B.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	2013
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3984054/ https://ncbi.nlm.nih.gov/pubmed/24183589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.022
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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells

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