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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells
During prion diseases, a normally benign, host protein, denoted PrP(C), undergoes alternative folding into the aberrant isoform, PrP(Sc). We used ELISA assays to identify and confirm hits in order to develop leads that reduce PrP(Sc) in prion-infected dividing and stationary-phase mouse neuroblastom...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984054/ https://ncbi.nlm.nih.gov/pubmed/24183589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.022 |
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