Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells

During prion diseases, a normally benign, host protein, denoted PrP(C), undergoes alternative folding into the aberrant isoform, PrP(Sc). We used ELISA assays to identify and confirm hits in order to develop leads that reduce PrP(Sc) in prion-infected dividing and stationary-phase mouse neuroblastom...

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Autores principales: Silber, B. Michael, Gever, Joel R., Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R., Widjaja, Kartika, Irwin, John J., Rao, Satish, Jacobson, Matthew P., Ghaemmaghami, Sina, Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984054/
https://ncbi.nlm.nih.gov/pubmed/24183589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.022
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