A scrapie-like unfolding intermediate of the prion protein domain PrP(121–231) induced by acidic pH
The infectious agent of transmissible spongiform encephalopathies is believed to consist of an oligomeric isoform, PrP(Sc), of the monomeric cellular prion protein, PrP(C). The conversion of PrP(C) to PrP(Sc) is characterized by a decrease in α-helical structure, an increase in β-sheet content, and...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6010 |
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