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A scrapie-like unfolding intermediate of the prion protein domain PrP(121–231) induced by acidic pH

The infectious agent of transmissible spongiform encephalopathies is believed to consist of an oligomeric isoform, PrP(Sc), of the monomeric cellular prion protein, PrP(C). The conversion of PrP(C) to PrP(Sc) is characterized by a decrease in α-helical structure, an increase in β-sheet content, and...

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Bibliografische gegevens
Hoofdauteurs: Hornemann, Simone, Glockshuber, Rudi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1998
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27576/
https://ncbi.nlm.nih.gov/pubmed/9600908
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