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Characterizing the inhibition of α‐synuclein oligomerization by a pharmacological chaperone that prevents prion formation by the protein PrP

Aggregation of the disordered protein α‐synuclein into amyloid fibrils is a central feature of synucleinopathies, neurodegenerative disorders that include Parkinson's disease. Small, pre‐fibrillar oligomers of misfolded α‐synuclein are thought to be the key toxic entities, and α‐synuclein misfo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Protein Sci
Päätekijät: Dong, Chunhua, Garen, Craig R., Mercier, Pascal, Petersen, Nils O., Woodside, Michael T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley & Sons, Inc. 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699102/
https://ncbi.nlm.nih.gov/pubmed/31306510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3684
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