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Unfolded and intermediate states of PrP play a key role in the mechanism of action of an antiprion chaperone
Prion and prion-like diseases involve the propagation of misfolded protein conformers. Small-molecule pharmacological chaperones can inhibit propagated misfolding, but how they interact with disease-related proteins to prevent misfolding is often unclear. We investigated how pentosan polysulfate (PP...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7936342/ https://ncbi.nlm.nih.gov/pubmed/33619087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010213118 |
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