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Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
SIMPLE SUMMARY: MLL-rearranged leukemia, driven by MLL-fusion proteins, is an aggressive, therapy-resistant leukemia found in >60% of infant leukemia and ~10% of adult leukemia. Studies have shown that inhibiting DOT1L enzymatic activity blocks leukemogenesis. However, DOT1L is critical for vario...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7914713/ https://ncbi.nlm.nih.gov/pubmed/33562706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040642 |
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