Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis

SIMPLE SUMMARY: MLL-rearranged leukemia, driven by MLL-fusion proteins, is an aggressive, therapy-resistant leukemia found in >60% of infant leukemia and ~10% of adult leukemia. Studies have shown that inhibiting DOT1L enzymatic activity blocks leukemogenesis. However, DOT1L is critical for vario...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancers (Basel)
Egile Nagusiak: Grigsby, Sierrah M., Friedman, Ann, Chase, Jennifer, Waas, Bridget, Ropa, James, Serio, Justin, Shen, Chenxi, Muntean, Andrew G., Maillard, Ivan, Nikolovska-Coleska, Zaneta
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914713/
https://ncbi.nlm.nih.gov/pubmed/33562706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13040642
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