Targeting Recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L): CHARACTERIZING THE INTERACTIONS BETWEEN DOT1L AND MIXED LINEAGE LEUKEMIA (MLL) FUSION PROTEINS

The MLL fusion proteins, AF9 and ENL, activate target genes in part via recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like). Here we report biochemical, biophysical, and functional characterization of the interaction between DOT1L and MLL fusion proteins, AF9...

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Detalhes bibliográficos
Main Authors: Shen, Chenxi, Jo, Stephanie Y., Liao, Chenzhong, Hess, Jay L., Nikolovska-Coleska, Zaneta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798529/
https://ncbi.nlm.nih.gov/pubmed/23996074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457135
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