Targeting Recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L): CHARACTERIZING THE INTERACTIONS BETWEEN DOT1L AND MIXED LINEAGE LEUKEMIA (MLL) FUSION PROTEINS

The MLL fusion proteins, AF9 and ENL, activate target genes in part via recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like). Here we report biochemical, biophysical, and functional characterization of the interaction between DOT1L and MLL fusion proteins, AF9...

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Autors principals: Shen, Chenxi, Jo, Stephanie Y., Liao, Chenzhong, Hess, Jay L., Nikolovska-Coleska, Zaneta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798529/
https://ncbi.nlm.nih.gov/pubmed/23996074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457135
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