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Targeting STAT3 with proteolysis targeting chimeras (PROTACs) and next generation antisense oligonucleotides

Signal transducer and activator of transcription 3 (STAT3) has been recognized for its key role in the progression of cancer, where it is frequently upregulated or constitutively hyperactivated, contributing to tumor cell proliferation, survival, and migration, as well as angiogenesis and suppressio...

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Bibliografski detalji
Izdano u:Mol Cancer Ther
Glavni autori: Shiah, Jamie V., Grandis, Jennifer R., Johnson, Daniel E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888537/
https://ncbi.nlm.nih.gov/pubmed/33203730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0599
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