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Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications
[Image: see text] Hetero-bifunctional PROteolysis TArgeting Chimeras (PROTACs) represent a new emerging class of small molecules designed to induce polyubiquitylation and proteasomal-dependent degradation of a target protein. Despite the increasing number of publications about the synthesis, biologi...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Med Chem |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical
Society
2020
|
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8015227/ https://ncbi.nlm.nih.gov/pubmed/33026811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00793 |
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