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Cholesterol as a modulator of cannabinoid receptor CB(2) signaling

Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB(2), we demonstrate that cholesterol increases basal activation levels of the receptor and alters the pha...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Yeliseev, Alexei, Iyer, Malliga R., Joseph, Thomas T., Coffey, Nathan J., Cinar, Resat, Zoubak, Lioudmila, Kunos, George, Gawrisch, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881127/
https://ncbi.nlm.nih.gov/pubmed/33580091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83245-6
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