Effects of Alcohol-Induced Increase in CYP2E1 Content in Human Liver Microsomes on the Activity and Cooperativity of CYP3A4

We investigate the effect of the alcohol-induced increase in the content of CYP2E1 in human liver microsomes (HLM) on the function of CYP3A4. Membrane incorporation of the purified CYP2E1 into HLM considerably increases the rate of metabolism of 7-benzyloxyquinoline (BQ) and attenuates the homotropi...

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Publicat a:Arch Biochem Biophys
Autors principals: Dangi, Bikash, Davydova, Nadezhda Y., Maldonado, Marc A., Abbasi, Armina, Vavilov, Nikita E., Zgoda, Victor G., Davydov, Dmitri R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856178/
https://ncbi.nlm.nih.gov/pubmed/33197431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108677
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