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Towards a systems approach to the human cytochrome P450 ensemble: Interactions between CYP2D6 and CYP2E1 and their functional consequences

Functional cross-talk among human drug-metabolizing cytochromes P450 through their association is a topic of emerging importance. Here we studied the interactions of human CYP2D6, a major metabolizer of psychoactive drugs, with one of the most prevalent human P450 enzymes, ethanol-inducible CYP2E1....

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Davydov, Dmitri R., Davydova, Nadezhda Y., Rodgers, John T., Rushmore, Thomas H., Jones, Jeffrey P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798876/
https://ncbi.nlm.nih.gov/pubmed/28904078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170543
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