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Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

In this study we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system we used CYP2E1-enriched human liver microsomes (HLM) obtained by incorporation of purified CYP2E1. Using a technique ba...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Davydova, Nadezhda Y., Dangi, Bikash, Maldonado, Marc A., Vavilov, Nikita E., Zgoda, Victor G., Davydov, Dmitri R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085345/
https://ncbi.nlm.nih.gov/pubmed/31750875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190532
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