Probing Functional Interactions between Cytochromes P450 with Principal Component Analysis of Substrate Saturation Profiles and Targeted Proteomics

We investigated the correspondence between drug metabolism routes and the composition of the P450 ensemble in human liver microsomes (HLM). As a probe, we used Coumarin 152 (C152), a fluorogenic substrate metabolized by multiple P450 species. Studying the substrate-saturation profiles (SSP) in seven...

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Bibliographic Details
Published in:Arch Biochem Biophys
Main Authors: Dangi, Bikash, Davydova, Nadezhda Y., Maldonado, Marc A., Ahire, Deepak, Prasad, Bhagwat, Davydov, Dmitri R.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260145/
https://ncbi.nlm.nih.gov/pubmed/34058150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2021.108937
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