Probing Functional Interactions between Cytochromes P450 with Principal Component Analysis of Substrate Saturation Profiles and Targeted Proteomics

We investigated the correspondence between drug metabolism routes and the composition of the P450 ensemble in human liver microsomes (HLM). As a probe, we used Coumarin 152 (C152), a fluorogenic substrate metabolized by multiple P450 species. Studying the substrate-saturation profiles (SSP) in seven...

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Publicado en:Arch Biochem Biophys
Main Authors: Dangi, Bikash, Davydova, Nadezhda Y., Maldonado, Marc A., Ahire, Deepak, Prasad, Bhagwat, Davydov, Dmitri R.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260145/
https://ncbi.nlm.nih.gov/pubmed/34058150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2021.108937
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