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Probing Functional Interactions between Cytochromes P450 with Principal Component Analysis of Substrate Saturation Profiles and Targeted Proteomics
We investigated the correspondence between drug metabolism routes and the composition of the P450 ensemble in human liver microsomes (HLM). As a probe, we used Coumarin 152 (C152), a fluorogenic substrate metabolized by multiple P450 species. Studying the substrate-saturation profiles (SSP) in seven...
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| Izdano u: | Arch Biochem Biophys |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8260145/ https://ncbi.nlm.nih.gov/pubmed/34058150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2021.108937 |
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