Nonadditivity in Human Microsomal Drug Metabolism Revealed in a Study with Coumarin 152, a Polyspecific Cytochrome P450 Substrate

1. We closely characterized 7-Dimethylamino-4-trifluromethylcoumarin (Coumarin 152, C152), a substrate metabolized by multiple P450 species, to establish a new fluorogenic probe for the studies of functional integration in the cytochrome P450 ensemble, 2. Scanning fluorescence spectroscopy and LC/MS...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Xenobiotica
Egile Nagusiak: Dangi, Bikash, Davydova, Nadezhda Y., Vavilov, Nikita E., Zgoda, Victor G., Davydov, Dmitri R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7740640/
https://ncbi.nlm.nih.gov/pubmed/32662751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2020.1775913
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