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Nonadditivity in Human Microsomal Drug Metabolism Revealed in a Study with Coumarin 152, a Polyspecific Cytochrome P450 Substrate
1. We closely characterized 7-Dimethylamino-4-trifluromethylcoumarin (Coumarin 152, C152), a substrate metabolized by multiple P450 species, to establish a new fluorogenic probe for the studies of functional integration in the cytochrome P450 ensemble, 2. Scanning fluorescence spectroscopy and LC/MS...
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| 發表在: | Xenobiotica |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7740640/ https://ncbi.nlm.nih.gov/pubmed/32662751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2020.1775913 |
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