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Effects of Alcohol-Induced Increase in CYP2E1 Content in Human Liver Microsomes on the Activity and Cooperativity of CYP3A4
We investigate the effect of the alcohol-induced increase in the content of CYP2E1 in human liver microsomes (HLM) on the function of CYP3A4. Membrane incorporation of the purified CYP2E1 into HLM considerably increases the rate of metabolism of 7-benzyloxyquinoline (BQ) and attenuates the homotropi...
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| Опубликовано в: : | Arch Biochem Biophys |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7856178/ https://ncbi.nlm.nih.gov/pubmed/33197431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2020.108677 |
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