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Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates
Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor‐selective treatment options. A hydrophilic β‐glucuronidase‐cleavable linker was used to connect the highly potent antimitotic ag...
में बचाया:
| में प्रकाशित: | Chemistry |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley and Sons Inc.
2020
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7839693/ https://ncbi.nlm.nih.gov/pubmed/32955139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003471 |
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