Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers. The conjugates were able to effectively inhibit binding o...

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Bibliografiske detaljer
Udgivet i:ChemistryOpen
Main Authors: Borbély, Adina, Figueras, Eduard, Martins, Ana, Bodero, Lizeth, Raposo Moreira Dias, André, López Rivas, Paula, Pina, Arianna, Arosio, Daniela, Gallinari, Paola, Frese, Marcel, Steinkühler, Christian, Gennari, Cesare, Piarulli, Umberto, Sewald, Norbert
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
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Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587324/
https://ncbi.nlm.nih.gov/pubmed/31275795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900110
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