Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers. The conjugates were able to effectively inhibit binding o...

詳細記述

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書誌詳細
出版年:ChemistryOpen
主要な著者: Borbély, Adina, Figueras, Eduard, Martins, Ana, Bodero, Lizeth, Raposo Moreira Dias, André, López Rivas, Paula, Pina, Arianna, Arosio, Daniela, Gallinari, Paola, Frese, Marcel, Steinkühler, Christian, Gennari, Cesare, Piarulli, Umberto, Sewald, Norbert
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
Full Papers
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587324/
https://ncbi.nlm.nih.gov/pubmed/31275795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201900110
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