Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified α(V)β(3) receptor, retaining good binding affinity,...

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Publicado en:Beilstein J Org Chem
Autores principales: Bodero, Lizeth, López Rivas, Paula, Korsak, Barbara, Hechler, Torsten, Pahl, Andreas, Müller, Christoph, Arosio, Daniela, Pignataro, Luca, Gennari, Cesare, Piarulli, Umberto
Formato: Artigo
Lenguaje:Inglês
Publicado: Beilstein-Institut 2018
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Full Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827777/
https://ncbi.nlm.nih.gov/pubmed/29520305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.29
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