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Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting
RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified α(V)β(3) receptor, retaining good binding affinity,...
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| Publicado no: | Beilstein J Org Chem |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5827777/ https://ncbi.nlm.nih.gov/pubmed/29520305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.14.29 |
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