Cyclic RGD and isoDGR Integrin Ligands Containing cis-2-amino-1-cyclopentanecarboxylic (cis-β-ACPC) Scaffolds

Integrin ligands containing the tripeptide sequences Arg-Gly-Asp (RGD) and iso-Asp-Gly- Arg (isoDGR) were actively investigated as inhibitors of tumor angiogenesis and directing unit in tumor-targeting drug conjugates. Reported herein is the synthesis, of two RGD and one isoDGR cyclic peptidomimetic...

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Publicat a:Molecules
Autors principals: Panzeri, Silvia, Arosio, Daniela, Gazzola, Silvia, Belvisi, Laura, Civera, Monica, Potenza, Donatella, Vasile, Francesca, Kemker, Isabell, Ertl, Thomas, Sewald, Norbert, Reiser, Oliver, Piarulli, Umberto
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766232/
https://ncbi.nlm.nih.gov/pubmed/33339382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25245966
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