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Linker Hydrophilicity Modulates the Anticancer Activity of RGD–Cryptophycin Conjugates
Most anticancer agents are hydrophobic and can easily penetrate the tumor cell membrane by passive diffusion. This may impede the development of highly effective and tumor‐selective treatment options. A hydrophilic β‐glucuronidase‐cleavable linker was used to connect the highly potent antimitotic ag...
Tallennettuna:
| Julkaisussa: | Chemistry |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
John Wiley and Sons Inc.
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7839693/ https://ncbi.nlm.nih.gov/pubmed/32955139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003471 |
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