Synthesis and Biological Characterization of Monomeric and Tetrameric RGD‐Cryptophycin Conjugates

The effective delivery of cytotoxic agents to tumor cells is a key challenge in anticancer therapy. Multivalent integrinspecific ligands are considered a promising tool to increase the binding affinity, selectivity, and internalization efficiency of small‐molecule drug conjugates. Herein, we report...

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Bibliographic Details
Published in:Chemistry
Main Authors: Borbély, Adina, Thoreau, Fabien, Figueras, Eduard, Kadri, Malika, Coll, Jean‐Luc, Boturyn, Didier, Sewald, Norbert
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064988/
https://ncbi.nlm.nih.gov/pubmed/31943410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201905437
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