Synthesis and Biological Characterization of Monomeric and Tetrameric RGD‐Cryptophycin Conjugates

The effective delivery of cytotoxic agents to tumor cells is a key challenge in anticancer therapy. Multivalent integrinspecific ligands are considered a promising tool to increase the binding affinity, selectivity, and internalization efficiency of small‐molecule drug conjugates. Herein, we report...

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Vydáno v:Chemistry
Hlavní autoři: Borbély, Adina, Thoreau, Fabien, Figueras, Eduard, Kadri, Malika, Coll, Jean‐Luc, Boturyn, Didier, Sewald, Norbert
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064988/
https://ncbi.nlm.nih.gov/pubmed/31943410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201905437
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