Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability

Catalytically inactive Cas9 (dCas9) has become an increasingly popular tool for targeted gene activation/inactivation, live-cell imaging, and base editing. While dCas9 was reported to induce base substitutions and indels, it has not been associated with structural variations. Here, we show that dCas...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Doi, Goro, Okada, Satoshi, Yasukawa, Takehiro, Sugiyama, Yuki, Bala, Siqin, Miyazaki, Shintaro, Kang, Dongchon, Ito, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826275/
https://ncbi.nlm.nih.gov/pubmed/33398345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1241
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