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Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability
The postreplication repair gene, HLTF, is often amplified and overexpressed in cancer. Here we model HLTF dysregulation through the functionally conserved Saccharomyces cerevisiae ortholog, RAD5. Genetic interaction profiling and landscape enrichment analysis of RAD5 overexpression (RAD5(OE)) reveal...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6753471/ https://ncbi.nlm.nih.gov/pubmed/31350889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz631 |
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