Separase prevents genomic instability by controlling replication fork speed

Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin comple...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D’Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758895/
https://ncbi.nlm.nih.gov/pubmed/29165708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1172
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