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Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA damage checkpoint function. Using a yeast model sys...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344861/ https://ncbi.nlm.nih.gov/pubmed/30476303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1195 |
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