Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function

Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA damage checkpoint function. Using a yeast model sys...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Gellon, Lionel, Kaushal, Simran, Cebrián, Jorge, Lahiri, Mayurika, Mirkin, Sergei M, Freudenreich, Catherine H
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344861/
https://ncbi.nlm.nih.gov/pubmed/30476303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1195
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