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Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function
Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA damage checkpoint function. Using a yeast model sys...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344861/ https://ncbi.nlm.nih.gov/pubmed/30476303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1195 |
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