Double-Strand Break Repair Pathways Protect against CAG/CTG Repeat Expansions, Contractions and Repeat-Mediated Chromosomal Fragility in Saccharomyces cerevisiae

Trinucleotide repeats can form secondary structures, whose inappropriate repair or replication can lead to repeat expansions. There are multiple loci within the human genome where expansion of trinucleotide repeats leads to disease. Although it is known that expanded repeats accumulate double-strand...

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Bibliografski detalji
Glavni autori: Sundararajan, Rangapriya, Gellon, Lionel, Zunder, Rachel M., Freudenreich, Catherine H.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2010
Teme:
Investigations
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815931/
https://ncbi.nlm.nih.gov/pubmed/19901069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.111039
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