Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function

Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA damage checkpoint function. Using a yeast model sys...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Gellon, Lionel, Kaushal, Simran, Cebrián, Jorge, Lahiri, Mayurika, Mirkin, Sergei M, Freudenreich, Catherine H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344861/
https://ncbi.nlm.nih.gov/pubmed/30476303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1195
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