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Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability
Catalytically inactive Cas9 (dCas9) has become an increasingly popular tool for targeted gene activation/inactivation, live-cell imaging, and base editing. While dCas9 was reported to induce base substitutions and indels, it has not been associated with structural variations. Here, we show that dCas...
Shranjeno v:
| izdano v: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7826275/ https://ncbi.nlm.nih.gov/pubmed/33398345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1241 |
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