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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
Genome editing by Cas9, which cleaves double-stranded DNA at a sequence programmed by a short single-guide RNA (sgRNA), can result in off-target DNA modification that may be detrimental in some applications. To improve DNA cleavage specificity, we generated fusions of catalytically inactive Cas9 and...
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| Izdano u: | Nat Biotechnol |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263420/ https://ncbi.nlm.nih.gov/pubmed/24770324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2909 |
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