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Allele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers

INTRODUCTION: Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized in terms of oncogenic function and drug sensitivity. Herein, we characterize the subset of lung adenocarcinoma harboring EGFR L861Q through both preclinical and clinical investigations. EXPERIMENT...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Thorac Oncol
Egile Nagusiak: Sato, Hiroki, Offin, Michael, Kubota, Daisuke, Yu, Helena A., Wilhelm, Clare, Toyooka, Shinichi, Somwar, Romel, Kris, Mark G., Ladanyi, Marc
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775889/
https://ncbi.nlm.nih.gov/pubmed/33038514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2020.09.019
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