Allele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers

INTRODUCTION: Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized in terms of oncogenic function and drug sensitivity. Herein, we characterize the subset of lung adenocarcinoma harboring EGFR L861Q through both preclinical and clinical investigations. EXPERIMENT...

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Publicado en:J Thorac Oncol
Autores principales: Sato, Hiroki, Offin, Michael, Kubota, Daisuke, Yu, Helena A., Wilhelm, Clare, Toyooka, Shinichi, Somwar, Romel, Kris, Mark G., Ladanyi, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775889/
https://ncbi.nlm.nih.gov/pubmed/33038514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2020.09.019
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