Allele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers

INTRODUCTION: Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized in terms of oncogenic function and drug sensitivity. Herein, we characterize the subset of lung adenocarcinoma harboring EGFR L861Q through both preclinical and clinical investigations. EXPERIMENT...

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Vydáno v:J Thorac Oncol
Hlavní autoři: Sato, Hiroki, Offin, Michael, Kubota, Daisuke, Yu, Helena A., Wilhelm, Clare, Toyooka, Shinichi, Somwar, Romel, Kris, Mark G., Ladanyi, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775889/
https://ncbi.nlm.nih.gov/pubmed/33038514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2020.09.019
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