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Brief report: EGFR L858M/L861Q cis mutations confer selective sensitivity to afatinib

INTRODUCTION: Tyrosine kinase inhibitors (TKIs) have been developed to treat patients with epidermal growth factor receptor (EGFR)-mutant lung cancers. However, the therapeutic efficacy of TKIs in patients with uncommon EGFR mutations remains unclear. METHODS: Next-generation sequencing was performe...

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Publicado en:J Thorac Oncol
Autores principales: Saxon, Jamie A., Sholl, Lynette M., Jänne, Pasi A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558893/
https://ncbi.nlm.nih.gov/pubmed/28088511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2017.01.006
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