Acquired BRAF rearrangements induce secondary resistance to EGFR therapy in EGFR-mutated lung cancers

INTRODUCTION: Multiple genetic mechanisms have been identified in EGFR-mutant lung cancers as mediators of acquired resistance (AR) to EGFR tyrosine kinase inhibitors (TKI) but many cases still lack a known mechanism. METHODS: To identify novel mechanisms of AR, we performed targeted large panel seq...

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Pubblicato in:J Thorac Oncol
Autori principali: Vojnic, Morana, Kubota, Daisuke, Kurzatkowski, Christopher, Offin, Michael, Suzawa, Ken, Benayed, Ryma, Schoenfeld, Adam J., Plodkowski, Andrew J., Poirier, John T., Rudin, Charles M., Kris, Mark G., Rosen, Neal X., Yu, Helena A., Riely, Gregory J., Arcila, Maria E., Somwar, Romel, Ladanyi, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486868/
https://ncbi.nlm.nih.gov/pubmed/30831205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2018.12.038
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