Acquired BRAF rearrangements induce secondary resistance to EGFR therapy in EGFR-mutated lung cancers

INTRODUCTION: Multiple genetic mechanisms have been identified in EGFR-mutant lung cancers as mediators of acquired resistance (AR) to EGFR tyrosine kinase inhibitors (TKI) but many cases still lack a known mechanism. METHODS: To identify novel mechanisms of AR, we performed targeted large panel seq...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Thorac Oncol
Prif Awduron: Vojnic, Morana, Kubota, Daisuke, Kurzatkowski, Christopher, Offin, Michael, Suzawa, Ken, Benayed, Ryma, Schoenfeld, Adam J., Plodkowski, Andrew J., Poirier, John T., Rudin, Charles M., Kris, Mark G., Rosen, Neal X., Yu, Helena A., Riely, Gregory J., Arcila, Maria E., Somwar, Romel, Ladanyi, Marc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486868/
https://ncbi.nlm.nih.gov/pubmed/30831205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2018.12.038
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