Acquired BRAF rearrangements induce secondary resistance to EGFR therapy in EGFR-mutated lung cancers

INTRODUCTION: Multiple genetic mechanisms have been identified in EGFR-mutant lung cancers as mediators of acquired resistance (AR) to EGFR tyrosine kinase inhibitors (TKI) but many cases still lack a known mechanism. METHODS: To identify novel mechanisms of AR, we performed targeted large panel seq...

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Publicat a:J Thorac Oncol
Autors principals: Vojnic, Morana, Kubota, Daisuke, Kurzatkowski, Christopher, Offin, Michael, Suzawa, Ken, Benayed, Ryma, Schoenfeld, Adam J., Plodkowski, Andrew J., Poirier, John T., Rudin, Charles M., Kris, Mark G., Rosen, Neal X., Yu, Helena A., Riely, Gregory J., Arcila, Maria E., Somwar, Romel, Ladanyi, Marc
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486868/
https://ncbi.nlm.nih.gov/pubmed/30831205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2018.12.038
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