Acquired BRAF rearrangements induce secondary resistance to EGFR therapy in EGFR-mutated lung cancers

INTRODUCTION: Multiple genetic mechanisms have been identified in EGFR-mutant lung cancers as mediators of acquired resistance (AR) to EGFR tyrosine kinase inhibitors (TKI) but many cases still lack a known mechanism. METHODS: To identify novel mechanisms of AR, we performed targeted large panel seq...

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Publicado en:J Thorac Oncol
Autores principales: Vojnic, Morana, Kubota, Daisuke, Kurzatkowski, Christopher, Offin, Michael, Suzawa, Ken, Benayed, Ryma, Schoenfeld, Adam J., Plodkowski, Andrew J., Poirier, John T., Rudin, Charles M., Kris, Mark G., Rosen, Neal X., Yu, Helena A., Riely, Gregory J., Arcila, Maria E., Somwar, Romel, Ladanyi, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486868/
https://ncbi.nlm.nih.gov/pubmed/30831205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2018.12.038
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