Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers

NRG1 rearrangements are oncogenic drivers that are enriched in invasive mucinous adenocarcinomas (IMAs) of the lung. The oncoprotein binds ERBB3-ERBB2 heterodimers and activates downstream signaling, supporting a therapeutic paradigm of ERBB3/ERBB2 inhibition. As proof of concept, a durable response...

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Published in:Cancer Discov
Main Authors: Drilon, Alexander, Somwar, Romel, Mangatt, Biju P., Edgren, Henrik, Desmeules, Patrice, Ruusulehto, Anja, Smith, Roger S., Delasos, Lukas, Vojnic, Morana, Plodkowski, Andrew J., Sabari, Joshua, Ng, Kenneth, Montecalvo, Joseph, Chang, Jason, Tai, Huichun, Lockwood, William W., Martinez, Victor, Riely, Gregory J., Rudin, Charles M., Kris, Mark G., Arcila, Maria E., Matheny, Christopher, Benayed, Ryma, Rekhtman, Natasha, Ladanyi, Marc, Ganji, Gopinath
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984717/
https://ncbi.nlm.nih.gov/pubmed/29610121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1004
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