Allele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers

INTRODUCTION: Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized in terms of oncogenic function and drug sensitivity. Herein, we characterize the subset of lung adenocarcinoma harboring EGFR L861Q through both preclinical and clinical investigations. EXPERIMENT...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Thorac Oncol
Prif Awduron: Sato, Hiroki, Offin, Michael, Kubota, Daisuke, Yu, Helena A., Wilhelm, Clare, Toyooka, Shinichi, Somwar, Romel, Kris, Mark G., Ladanyi, Marc
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7775889/
https://ncbi.nlm.nih.gov/pubmed/33038514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2020.09.019
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