Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB(2) Receptor

Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB(2) receptor. These compounds selectively target CB(2) versus CB(...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756656/
https://ncbi.nlm.nih.gov/pubmed/32794211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003389
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