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Binding modes and selectivity of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands

The cannabinoid (CB) receptors (CB(1)R and CB(2)R) represent a promising therapeutic target for several indications such as nociception and obesity. The ligands with non-selectivity can be traced to the high similarity in the binding sites of both cannabinoid receptors. Therefore, the need for selec...

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Bibliographische Detailangaben
Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Yang, Jing-Fang, Williams, Alexander H., Penthala, Narsimha R., Prather, Paul L., Crooks, Peter A., Zhan, Chang-Guo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756905/
https://ncbi.nlm.nih.gov/pubmed/32997485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00551
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